Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms

Asthma is a chronic allergic inflammatory airway disease caused by aberrant immune responses to inhaled allergens, which leads to airway hyperresponsiveness (AHR) to contractile stimuli and airway obstruction. Blocking T helper 2 (T(H)2) differentiation represents a viable therapeutic strategy for a...

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Pubblicato in:Sci Signal
Autori principali: Singh, Brenal K., Lu, Wen, Schmidt Paustian, Amanda M., Ge, Moyar Q., Koziol-White, Cynthia J., Flayer, Cameron H., Killingbeck, Sara S., Wang, Nadan, Dong, Xinzhong, Riese, Matthew J., Deshpande, Deepak A., Panettieri, Reynold A., Haczku, Angela, Kambayashi, Taku
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996596/
https://ncbi.nlm.nih.gov/pubmed/31481522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aax3332
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