Respiratory supercomplexes act as a platform for complex III‐mediated maturation of human mitochondrial complexes I and IV

Mitochondrial respiratory chain (MRC) enzymes associate in supercomplexes (SCs) that are structurally interdependent. This may explain why defects in a single component often produce combined enzyme deficiencies in patients. A case in point is the alleged destabilization of complex I in the absence...

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Bibliographic Details
Published in:EMBO J
Main Authors: Protasoni, Margherita, Pérez‐Pérez, Rafael, Lobo‐Jarne, Teresa, Harbour, Michael E, Ding, Shujing, Peñas, Ana, Diaz, Francisca, Moraes, Carlos T, Fearnley, Ian M, Zeviani, Massimo, Ugalde, Cristina, Fernández‐Vizarra, Erika
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996572/
https://ncbi.nlm.nih.gov/pubmed/31912925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102817
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