Bufotenine, a tryptophan-derived alkaloid, suppresses the symptoms and increases the survival rate of rabies-infected mice: the development of a pharmacological approach for rabies treatment

BACKGROUND: Between 40,000-70,000 people die yearly of rabies, an incurable disease. Besides post-bite vaccination, no treatment is available for it. METHODS: First, virus dilution for antiviral effects in mice was determined. Then, animals were treated as follows: control (NaCl 250 µL/animal/day);...

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Vydáno v:J Venom Anim Toxins Incl Trop Dis
Hlavní autoři: Vigerelli, Hugo, Sciani, Juliana M., Pereira, Patricia M. C., Lavezo, Aline A., Silva, Andrea C. R., Collaço, Rita C. O., Rocha, Thalita, Bueno, Thais C., Pimenta, Daniel C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Centro de Estudos de Venenos e Animais Peçonhentos 2020
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996410/
https://ncbi.nlm.nih.gov/pubmed/32071597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1678-9199-JVATITD-2019-0050
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