Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice

Icosabutate is a structurally engineered eicosapentaenoic acid derivative under development for nonalcoholic steatohepatitis (NASH). In this study, we investigated the absorption and distribution properties of icosabutate in relation to liver targeting and used rodents to evaluate the effects of ico...

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Detalhes bibliográficos
Publicado no:Hepatol Commun
Main Authors: van den Hoek, Anita M., Pieterman, Elsbet J., van der Hoorn, José W., Iruarrizaga‐Lejarreta, Marta, Alonso, Cristina, Verschuren, Lars, Skjæret, Tore, Princen, Hans M.G., Fraser, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996349/
https://ncbi.nlm.nih.gov/pubmed/32025605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1453
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