Activation of General Control Nonderepressible-2 Kinase Ameliorates Glucotoxicity in Human Peritoneal Mesothelial Cells, Preserves Their Integrity, and Prevents Mesothelial to Mesenchymal Transition

Along with infections, ultrafiltration failure due to the toxicity of glucose-containing peritoneal dialysis (PD) solutions is the Achilles’ heel of PD method. Triggered by the protective effect of general control nonderepressible-2 (GCN-2) kinase activation against high-glucose conditions in other...

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Veröffentlicht in:Biomolecules
Hauptverfasser: Eleftheriadis, Theodoros, Pissas, Georgios, Antoniadi, Georgia, Nikolaou, Evdokia, Golfinopoulos, Spyridon, Liakopoulos, Vassilios, Stefanidis, Ioannis
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995539/
https://ncbi.nlm.nih.gov/pubmed/31817562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9120832
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