Precise CRISPR/Cas9 editing of the NHE1 gene renders chickens resistant to the J subgroup of avian leukosis virus

Avian leukosis virus subgroup J (ALV-J) is an important concern for the poultry industry. Replication of ALV-J depends on a functional cellular receptor, the chicken Na(+)/H(+) exchanger type 1 (chNHE1). Tryptophan residue number 38 of chNHE1 (W38) in the extracellular portion of this molecule is a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Koslová, Anna, Trefil, Pavel, Mucksová, Jitka, Reinišová, Markéta, Plachý, Jiří, Kalina, Jiří, Kučerová, Dana, Geryk, Josef, Krchlíková, Veronika, Lejčková, Barbora, Hejnar, Jiří
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995012/
https://ncbi.nlm.nih.gov/pubmed/31964810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913827117
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