Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes

Glucocorticoids (GCs) are a central component of therapy for patients with T cell acute lymphoblastic leukemia (T-ALL), and although resistance to GCs is a strong negative prognostic indicator in T-ALL, the mechanisms of GC resistance remain poorly understood. Using diagnostic samples from patients...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Meyer, Lauren K., Huang, Benjamin J., Delgado-Martin, Cristina, Roy, Ritu P., Hechmer, Aaron, Wandler, Anica M., Vincent, Tiffaney L., Fortina, Paolo, Olshen, Adam B., Wood, Brent L., Horton, Terzah M., Shannon, Kevin M., Teachey, David T., Hermiston, Michelle L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994137/
https://ncbi.nlm.nih.gov/pubmed/31687977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130189
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