Genetic polymorphism in C3 is associated with progression in chronic kidney disease (CKD) patients with IgA nephropathy but not in other causes of CKD

OBJECTIVES: The R102G variant in complement 3 (C3) results in two allotypic variants: C3 fast (C3F) and C3 slow (C3S). C3F presents at increased frequency in patients with chronic kidney disease (CKD), our aim is to explore its role in CKD progression and mortality. METHODS: Delta (Δ) eGFR for 2038...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Ibrahim, Sara T., Chinnadurai, Rajkumar, Ali, Ibrahim, Payne, Debbie, Rice, Gillian I., Newman, William G., Algohary, Eman, Adam, Ahmed G., Kalra, Philip A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994105/
https://ncbi.nlm.nih.gov/pubmed/32004338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228101
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