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Tolerance to Selenoprotein Loss Differs between Human and Mouse
Mouse has emerged as the most common model organism in biomedicine. Here, we analyzed the tolerance to the loss-of-function (LoF) of selenoprotein genes, estimated from mouse knockouts and the frequency of LoF variants in humans. We found not only a general correspondence in tolerance (e.g., GPX1, G...
Gespeichert in:
| Veröffentlicht in: | Mol Biol Evol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6993852/ https://ncbi.nlm.nih.gov/pubmed/31560400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msz218 |
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