Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy

Immune checkpoint blockade targeting PD-1/PD-L1 has promising therapeutic efficacy in a variety of tumors, but resistance during treatment is a major issue. In this review, we describe the utility of PD-L1 expression levels, mutation burden, immune cell infiltration, and immune cell function for pre...

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Publicado en:Mol Cancer
Autores principales: Ren, Daixi, Hua, Yuze, Yu, Boyao, Ye, Xin, He, Ziheng, Li, Chunwei, Wang, Jie, Mo, Yongzhen, Wei, Xiaoxu, Chen, Yunhua, Zhou, Yujuan, Liao, Qianjin, Wang, Hui, Xiang, Bo, Zhou, Ming, Li, Xiaoling, Li, Guiyuan, Li, Yong, Zeng, Zhaoyang, Xiong, Wei
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993488/
https://ncbi.nlm.nih.gov/pubmed/32000802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-020-1144-6
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