Impact of NPM1/FLT3-ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

Patients with acute myeloid leukemia (AML) harboring FLT3 internal tandem duplications (ITDs) have poor outcomes, in particular AML with a high (≥0.5) mutant/wild-type allelic ratio (AR). The 2017 European LeukemiaNet (ELN) recommendations defined 4 distinct FLT3-ITD genotypes based on the ITD AR an...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Döhner, Konstanze, Thiede, Christian, Jahn, Nikolaus, Panina, Ekaterina, Gambietz, Agnes, Larson, Richard A., Prior, Thomas W., Marcucci, Guido, Jones, Dan, Krauter, Jürgen, Heuser, Michael, Voso, Maria Teresa, Ottone, Tiziana, Nomdedeu, Josep F., Mandrekar, Sumithra J., Klisovic, Rebecca B., Wei, Andrew H., Sierra, Jorge, Sanz, Miguel A., Brandwein, Joseph M., de Witte, Theo, Jansen, Joop H., Niederwieser, Dietger, Appelbaum, Frederick R., Medeiros, Bruno C., Tallman, Martin S., Schlenk, Richard F., Ganser, Arnold, Serve, Hubert, Ehninger, Gerhard, Amadori, Sergio, Gathmann, Insa, Benner, Axel, Pallaud, Celine, Stone, Richard M., Döhner, Hartmut, Bloomfield, Clara D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993016/
https://ncbi.nlm.nih.gov/pubmed/31826241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002697
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