Effect of Concurrent Chemoradiation With Celecoxib vs Concurrent Chemoradiation Alone on Survival Among Patients With Non–Small Cell Lung Cancer With and Without Cyclooxygenase 2 Genetic Variants: A Phase 2 Randomized Clinical Trial

IMPORTANCE: Treatment of locally advanced non–small cell lung cancer (NSCLC) remains challenging. The rationale of combining a cyclooxygenase 2 (COX-2) inhibitor with concurrent chemoradiation (CCRT) was based on results of preclinical research and prospective clinical studies; however, no randomize...

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Vydáno v:JAMA Netw Open
Hlavní autoři: Bi, Nan, Liang, Jun, Zhou, Zongmei, Chen, Dongfu, Fu, Zhixue, Yang, Xu, Feng, QinFu, Hui, Zhouguang, Xiao, Zefen, Lv, Jima, Wang, Xiaozhen, Zhang, Tao, Wang, Xin, Deng, Lei, Wang, Wenqing, Wang, Jingbo, Liu, Lipin, Hu, Chen, Wang, Luhua
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2019
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6991217/
https://ncbi.nlm.nih.gov/pubmed/31851351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2019.18070
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