Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation

SIRT1 and STAT3 are key to human aortic vascular smooth muscle cells (HAVSMCs) proliferation, migration and phenotypic transformation, but the regulatory mechanism of SIRT1-STAT3 in this process is still unclear. Septin4 is a cytoskeleton-related protein that regulates oxidative stress-vascular endo...

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Dettagli Bibliografici
Pubblicato in:Int J Biol Sci
Autori principali: Zhang, Naijin, Zhang, Ying, You, Shilong, Tian, Yichen, Lu, Saien, Cao, Liu, Sun, Yingxian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6990924/
https://ncbi.nlm.nih.gov/pubmed/32025217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.39843
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