Modeling medulloblastoma in vivo and with human cerebellar organoids

Medulloblastoma (MB) is the most common malignant brain tumor in children and among the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient-specific screen leading to the identification of Otx2 and c-MYC as strong Group 3 MB inducers. We validated our findings in human c...

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Vydáno v:Nat Commun
Hlavní autoři: Ballabio, Claudio, Anderle, Marica, Gianesello, Matteo, Lago, Chiara, Miele, Evelina, Cardano, Marina, Aiello, Giuseppe, Piazza, Silvano, Caron, Davide, Gianno, Francesca, Ciolfi, Andrea, Pedace, Lucia, Mastronuzzi, Angela, Tartaglia, Marco, Locatelli, Franco, Ferretti, Elisabetta, Giangaspero, Felice, Tiberi, Luca
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989674/
https://ncbi.nlm.nih.gov/pubmed/31996670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13989-3
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