Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren’s syndrome murine model

Autoimmune dacryoadenitis and altered lacrimal gland (LG) secretion are features of Sjögren’s syndrome (SS). Activity of cathepsin S (CTSS), a cysteine protease, is significantly and specifically increased in SS patient tears. The soluble chemokine, CX3CL1 (fractalkine), is cleaved from membrane-bou...

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Vydáno v:Sci Rep
Hlavní autoři: Fu, Runzhong, Guo, Hao, Janga, Srikanth, Choi, Minchang, Klinngam, Wannita, Edman, Maria C., Hamm-Alvarez, Sarah F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989636/
https://ncbi.nlm.nih.gov/pubmed/31996771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58337-4
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