A post hoc analysis of intra-subject coefficients of variation in pharmacokinetic measures to calculate optimal sample sizes for bioequivalence studies

Because bioequivalence studies are performed using a crossover design, information on the intra-subject coefficient of variation (intra-CV) for pharmacokinetic measures is needed when determining the sample size. However, calculated intra-CVs based on bioequivalence results of identical generic drug...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Transl Clin Pharmacol
Prif Awduron: Chung, Inbum, Oh, Jaeseong, Lee, SeungHwan, Jang, In-Jin, Lee, Youngjo, Chung, Jae-Yong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Korean Society for Clinical Pharmacology and Therapeutics 2018
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989220/
https://ncbi.nlm.nih.gov/pubmed/32055541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12793/tcp.2018.26.1.6
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