Binding of Host Cell Surface Protein Disulfide Isomerase by Anaplasma phagocytophilum Asp14 Enables Pathogen Infection

Diverse intracellular pathogens rely on eukaryotic cell surface disulfide reductases to invade host cells. Pharmacologic inhibition of these enzymes is cytotoxic, making it impractical for treatment. Identifying and mechanistically dissecting microbial proteins that co-opt surface reductases could r...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Green, Ryan S., Naimi, Waheeda A., Oliver, Lee D., O’Bier, Nathaniel, Cho, Jaehyung, Conrad, Daniel H., Martin, Rebecca K., Marconi, Richard T., Carlyon, Jason A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989111/
https://ncbi.nlm.nih.gov/pubmed/31992623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03141-19
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