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Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens

Trypanosoma brucei evades mammalian immunity by using recombination to switch its surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many subtelomeric multigene VSG expression sites are transcribed at a time. DNA repair activities have been implicated in the cataly...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Black, Jennifer Ann, Crouch, Kathryn, Lemgruber, Leandro, Lapsley, Craig, Dickens, Nicholas, Tosi, Luiz R.O., Mottram, Jeremy C., McCulloch, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988115/
https://ncbi.nlm.nih.gov/pubmed/31968257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.12.049
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