Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis

Acetyl-CoA carboxylase (ACC) catalyzes the rate-limiting step in de novo lipogenesis, which is increased in the livers of patients with nonalcoholic steatohepatitis. GS-0976 (firsocostat), an inhibitor of isoforms ACC1 and ACC2, reduced hepatic steatosis and serum fibrosis biomarkers such as tissue...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Matsumoto, Mitsuharu, Yashiro, Hiroaki, Ogino, Hitomi, Aoyama, Kazunobu, Nambu, Tadahiro, Nakamura, Sayuri, Nishida, Mayumi, Wang, Xiaolun, Erion, Derek M., Kaneko, Manami
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986730/
https://ncbi.nlm.nih.gov/pubmed/31990961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228212
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados