Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis

Acetyl-CoA carboxylase (ACC) catalyzes the rate-limiting step in de novo lipogenesis, which is increased in the livers of patients with nonalcoholic steatohepatitis. GS-0976 (firsocostat), an inhibitor of isoforms ACC1 and ACC2, reduced hepatic steatosis and serum fibrosis biomarkers such as tissue...

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Veröffentlicht in:PLoS One
Hauptverfasser: Matsumoto, Mitsuharu, Yashiro, Hiroaki, Ogino, Hitomi, Aoyama, Kazunobu, Nambu, Tadahiro, Nakamura, Sayuri, Nishida, Mayumi, Wang, Xiaolun, Erion, Derek M., Kaneko, Manami
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986730/
https://ncbi.nlm.nih.gov/pubmed/31990961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228212
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