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Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function

BACKGROUND: Nebulin is a critical thin filament-binding protein that spans from the Z-disk of the skeletal muscle sarcomere to near the pointed end of the thin filament. Its massive size and actin-binding property allows it to provide the thin filaments with structural and regulatory support. When t...

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Detalhes bibliográficos
Publicado no:Skelet Muscle
Main Authors: Li, Frank, Kolb, Justin, Crudele, Julie, Hourani, Zaynab, Smith, John E., Chamberlain, Jeffrey S., Granzier, Henk
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986074/
https://ncbi.nlm.nih.gov/pubmed/31992366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-019-0219-9
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