Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout

BACKGROUND: Genetic background affects serum urate concentration and gout risk, especially regarding these variants in the urate-transporter gene ABCG2. However, the role of epistasis between PKD2 and ABCG2 on the pathogenesis of gout is poorly understood. Here we assess this epistatic interaction i...

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Vydáno v:Hereditas
Hlavní autoři: Dong, Zheng, Zhou, Jingru, Jiang, Shuai, Li, Yuan, Zhao, Dongbao, Yang, Chengde, Ma, Yanyun, He, Hongjun, Ji, Hengdong, Jin, Li, Zou, Hejian, Wang, Jiucun
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986014/
https://ncbi.nlm.nih.gov/pubmed/32000861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41065-020-0116-6
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