Clinically relevant GSK-3β inhibitor 9-ING-41 is active as a single agent and in combination with other antitumor therapies in human renal cancer

Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, is involved in a broad range of pathological processes including cancer. GSK-3 has two isoforms, GSK-3α and GSK-3β, and GSK-3β has been recognized as a therapeutic target for the development of new anticancer drugs. The present study aim...

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Bibliographic Details
Published in:Int J Mol Med
Main Authors: Anraku, Tsutomu, Kuroki, Hiroo, Kazama, Akira, Bilim, Vladimir, Tasaki, Masaaki, Schmitt, Daniel, Mazar, Andrew, Giles, Francis J., Ugolkov, Andrey, Tomita, Yoshihiko
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984786/
https://ncbi.nlm.nih.gov/pubmed/31894292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2019.4427
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