The novel MAGL inhibitor MJN110 enhances responding to reward-predictive incentive cues by activation of CB1 receptors

CB1 receptor antagonists disrupt operant responding for food and drug reinforcers, and cue-induced reinstatement of cocaine and heroin seeking. Conversely, enhancing endocannabinoid signaling, particularly 2-arachidonyl glycerol (2-AG), by inhibition of monoacyl glycerol lipase (MAGL), may facilitat...

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Vydáno v:Neuropharmacology
Hlavní autoři: Feja, Malte, Leigh, Martin P.K., Baindur, Ajay N., McGraw, Justin J., Wakabayashi, Ken T., Cravatt, Benjamin F., Bass, Caroline E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983961/
https://ncbi.nlm.nih.gov/pubmed/31628934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.107814
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