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Activity and Affinity of Pin1 Variants

Pin1 is a peptidyl-prolyl isomerase responsible for isomerizing phosphorylated S/T-P motifs. Pin1 has two domains that each have a distinct ligand binding site, but only its PPIase domain has catalytic activity. Vast evidence supports interdomain allostery of Pin1, with binding of a ligand to its re...

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Bibliografiske detaljer
Udgivet i:Molecules
Main Authors: Born, Alexandra, Henen, Morkos A., Vögeli, Beat
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983177/
https://ncbi.nlm.nih.gov/pubmed/31861908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25010036
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