Single Cell Mass Cytometry Revealed the Immunomodulatory Effect of Cisplatin Via Downregulation of Splenic CD44+, IL-17A+ MDSCs and Promotion of Circulating IFN-γ+ Myeloid Cells in the 4T1 Metastatic Breast Cancer Model

The treatment of metastatic breast cancer remained a challenge despite the recent breakthrough in the immunotherapy regimens. Here, we addressed the multidimensional immunophenotyping of 4T1 metastatic breast cancer by the state-of-the-art single cell mass cytometry (CyTOF). We determined the dose a...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Balog, József Á., Hackler Jr., László, Kovács, Anita K., Neuperger, Patrícia, Alföldi, Róbert, Nagy, Lajos I., Puskás, László G., Szebeni, Gábor J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6982301/
https://ncbi.nlm.nih.gov/pubmed/31881770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21010170
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