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Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression
Despite the effectiveness of cisplatin as an anticancer agent, its trans-isomer, transplatin, is clinically ineffective. Although both isomers target nuclear DNA, there is a large difference in the magnitude of their biological effects. Here, we compared their effects on gene expression in an in vit...
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| Pubblicato in: | Int J Mol Sci |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6981875/ https://ncbi.nlm.nih.gov/pubmed/31861648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21010034 |
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