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Cell Communication Network Factor 4 (CCN4/WISP1) Shifts Melanoma Cells from a Fragile Proliferative State to a Resilient Metastatic State

INTRODUCTION: Cellular communication network factor 4 (CCN4/WISP1) is a secreted matricellular protein that stimulates metastasis in multiple malignancies but has an unclear impact on phenotypic changes in melanoma. Recent data using cells edited via a double-nickase CRISPR/Cas9 approach suggest tha...

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Detalhes bibliográficos
Publicado no:Cell Mol Bioeng
Main Authors: Deng, Wentao, Fernandez, Audry, McLaughlin, Sarah L., Klinke, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981335/
https://ncbi.nlm.nih.gov/pubmed/32030107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12195-019-00602-2
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