Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology

Studies have shown an overlap of Aβ plaques, tau tangles, and α-synuclein (α-syn) pathologies in the brains of Alzheimer’s disease (AD) and Parkinson’s disease (PD) with dementia (PDD) patients, with increased pathological burden correlating with severity of cognitive and motor symptoms. Despite the...

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Veröffentlicht in:Neuron
Hauptverfasser: Bassil, Fares, Brown, Hannah J., Pattabhiraman, Shankar, Iwasyk, Joe E., Maghames, Chantal M., Meymand, Emily S., Cox, Timothy O., Riddle, Dawn M., Zhang, Bin, Trojanowski, John Q., Lee, Virginia M-Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981053/
https://ncbi.nlm.nih.gov/pubmed/31759806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.10.010
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