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The impact of disregarding family structure on genome-wide association analysis of complex diseases in cohorts with simple pedigrees
The generalized linear mixed models (GLMMs) methodology is the standard framework for genome-wide association studies (GWAS) of complex diseases in family-based cohorts. Fitting GLMMs in very large cohorts, however, can be computationally demanding. Also, the modified versions of GLMM using faster a...
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| Publicat a: | J Appl Genet |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980752/ https://ncbi.nlm.nih.gov/pubmed/31755004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13353-019-00526-7 |
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