Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity

Mitochondrial function in white adipose tissue (WAT) is an important yet understudied aspect in adipocyte biology. Here, we report a role for amyloid precursor protein (APP) in compromising WAT mitochondrial function through a high-fat diet (HFD)-induced, unconventional mis-localization to mitochond...

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Détails bibliographiques
Publié dans:Nat Metab
Auteurs principaux: An, Yu A., Crewe, Clair, Asterholm, Ingrid Wernstedt, Sun, Kai, Chen, Shiuhwei, Zhang, Fang, Shao, Mengle, Funcke, Jan-Bernd, Zhang, Zhuzhen, Straub, Leon, Klein, Samuel, Kusminski, Christine M., Scherer, Philipp E.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980705/
https://ncbi.nlm.nih.gov/pubmed/31984308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0149-1
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