Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity

Mitochondrial function in white adipose tissue (WAT) is an important yet understudied aspect in adipocyte biology. Here, we report a role for amyloid precursor protein (APP) in compromising WAT mitochondrial function through a high-fat diet (HFD)-induced, unconventional mis-localization to mitochond...

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Detalhes bibliográficos
Publicado no:Nat Metab
Main Authors: An, Yu A., Crewe, Clair, Asterholm, Ingrid Wernstedt, Sun, Kai, Chen, Shiuhwei, Zhang, Fang, Shao, Mengle, Funcke, Jan-Bernd, Zhang, Zhuzhen, Straub, Leon, Klein, Samuel, Kusminski, Christine M., Scherer, Philipp E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980705/
https://ncbi.nlm.nih.gov/pubmed/31984308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0149-1
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