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Knocking out histone methyltransferase PRMT1 leads to stalled tadpole development and lethality in Xenopus tropicalis

BACKGROUND: Asymmetric arginine dimethylation of histone H4R3 to H4R3me2a by protein arginine methyltransferase 1 (PRMT1) has been implicated to play a key role in gene activation throughout vertebrates. PRMT1 knockout in mouse leads to embryonic lethality. This and the uterus-enclosed nature of the...

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Bibliografiske detaljer
Udgivet i:Biochim Biophys Acta Gen Subj
Main Authors: Shibata, Yuki, Okada, Morihiro, Miller, Thomas C., Shi, Yun-Bo
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980677/
https://ncbi.nlm.nih.gov/pubmed/31734465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2019.129482
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