Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase

A major challenge for new antibiotic discovery is predicting the physicochemical properties that enable small molecules to permeate Gram-negative bacterial membranes. We have applied physicochemical lessons from previous work to redesign and improve the antibacterial potency of pyridopyrimidine inhi...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Andrews, Logan D., Kane, Timothy R., Dozzo, Paola, Haglund, Cat M., Hilderbrandt, Darin J., Linsell, Martin S., Machajewski, Timothy, McEnroe, Glen, Serio, Alisa W., Wlasichuk, Kenneth B., Neau, David B., Pakhomova, Svetlana, Waldrop, Grover L., Sharp, Marc, Pogliano, Joe, Cirz, Ryan T., Cohen, Frederick
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980355/
https://ncbi.nlm.nih.gov/pubmed/31306011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00625
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