Reduced culture temperature attenuates oxidative stress and inflammatory response facilitating expansion and differentiation of adipose-derived stem cells

BACKGROUND: Adipose-derived stem cell (ASC) expansion under atmospheric oxygen levels (21%) was previously shown to cause increased reactive oxygen species (ROS) accumulation and genetic instability compared to cells cultured under physiological oxygen levels (2–8%). However, since culture under phy...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: Tirza, Gal, Solodeev, Inna, Sela, Meirav, Greenberg, Ilanit, Pasmanik-Chor, Metsada, Gur, Eyal, Shani, Nir
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6979291/
https://ncbi.nlm.nih.gov/pubmed/31973743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1542-0
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