Network Models Predict That Pyramidal Neuron Hyperexcitability and Synapse Loss in the dlPFC Lead to Age-Related Spatial Working Memory Impairment in Rhesus Monkeys

Behavioral studies have shown spatial working memory impairment with aging in several animal species, including humans. Persistent activity of layer 3 pyramidal dorsolateral prefrontal cortex (dlPFC) neurons during delay periods of working memory tasks is important for encoding memory of the stimulu...

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Udgivet i:Front Comput Neurosci
Main Authors: Ibañez, Sara, Luebke, Jennifer I., Chang, Wayne, Draguljić, Danel, Weaver, Christina M.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6979278/
https://ncbi.nlm.nih.gov/pubmed/32009920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncom.2019.00089
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