Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes

Background: NLRP3 inflammasome activation in response to several signals, including mitochondrial DNA (mDNA), regulates inflammatory responses by caspase-1 activation and interleukin-1β (IL-1β) release. Circulating mDNA is linked to micro and macrovascular complications in diabetes. However, a role...

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Bibliographic Details
Published in:Front Physiol
Main Authors: Pereira, Camila A., Carlos, Daniela, Ferreira, Nathanne S., Silva, Josiane F., Zanotto, Camila Z., Zamboni, Dario S., Garcia, Valéria D., Ventura, Dora Fix, Silva, João S., Tostes, Rita C.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978691/
https://ncbi.nlm.nih.gov/pubmed/32009974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01557
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