Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive immunity against a foreign, crosslinked prot...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Card, Catherine, Wilson, David S., Hirosue, Sachiko, Rincon-Restrepo, Marcela, de Titta, Alexandre, Güç, Esra, Martin, Coralie, Bain, Odile, Swartz, Melody A., Kilarski, Witold W.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978462/
https://ncbi.nlm.nih.gov/pubmed/31974398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57995-8
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