Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling

BACKGROUND: Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite sporadic reports of extra-motor symptoms, PLS is widely regarded as a pure upper motor neuron disorder. The post mortem lite...

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Vydáno v:Neuroimage Clin
Hlavní autoři: Finegan, Eoin, Li Hi Shing, Stacey, Chipika, Rangariroyashe H., Doherty, Mark A., Hengeveld, Jennifer C., Vajda, Alice, Donaghy, Colette, Pender, Niall, McLaughlin, Russell L., Hardiman, Orla, Bede, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978214/
https://ncbi.nlm.nih.gov/pubmed/31795059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nicl.2019.102089
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