Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas

Key to CRISPR-Cas adaptive immunity is maintaining an ongoing record of invading nucleic acids, a process carried out by the Cas1-Cas2 complex that integrates short segments of foreign genetic material (spacers) into the CRISPR locus. It is hypothesized that Cas1 evolved from casposases, a novel cla...

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Bibliographic Details
Published in:eLife
Main Authors: Hickman, Alison B, Kailasan, Shweta, Genzor, Pavol, Haase, Astrid D, Dyda, Fred
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Structural Biology and Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977970/
https://ncbi.nlm.nih.gov/pubmed/31913120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50004
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