Synthesis and validation of [(18)F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone

BACKGROUND: Targeted therapy of HER2 positive breast cancer has led to clinical success in some cases with primary and secondary resistance being major obstacles. Due to the substantial involvement of mTOR kinase in cell growth and proliferation pathways it is now targeted in combination treatments...

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Bibliografiska uppgifter
I publikationen:EJNMMI Radiopharm Chem
Huvudupphovsmän: Wichmann, Christian W., Goh, Yit Wooi, Parslow, Adam C., Rigopoulos, Angela, Guo, Nancy, Scott, Andrew M., Ackermann, Uwe, White, Jonathan M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer International Publishing 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977806/
https://ncbi.nlm.nih.gov/pubmed/31974638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41181-020-0089-9
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