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Synthesis and validation of [(18)F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone

BACKGROUND: Targeted therapy of HER2 positive breast cancer has led to clinical success in some cases with primary and secondary resistance being major obstacles. Due to the substantial involvement of mTOR kinase in cell growth and proliferation pathways it is now targeted in combination treatments...

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Detalhes bibliográficos
Publicado no:EJNMMI Radiopharm Chem
Main Authors: Wichmann, Christian W., Goh, Yit Wooi, Parslow, Adam C., Rigopoulos, Angela, Guo, Nancy, Scott, Andrew M., Ackermann, Uwe, White, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977806/
https://ncbi.nlm.nih.gov/pubmed/31974638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41181-020-0089-9
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