LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate

Methotrexate (MTX) is a folate analogue antimetabolite widely used for the treatment of rheumatoid arthritis and cancer. A number of studies have shown that MTX delivered via nanoparticle carriers is more potent against cancer cells than free MTX, a phenomenon attributed to higher cellular uptake of...

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Detalles Bibliográficos
Publicado en:Int J Pharm X
Autores principales: Al-Natour, Mohammad Ahmad, Alazzo, Ali, Ghaemmaghami, Amir M., Kim, Dong-Hyun, Alexander, Cameron
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
Materias:
Special section on SFNano 2018 meeting: Nanomedicine - from particle design to applications; edited by Dr. Nathalie Mignet, Dr. Chantal Pichon and Dr. Marie-Pierre Rols
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977166/
https://ncbi.nlm.nih.gov/pubmed/31993584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpx.2019.100036
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