Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis

Disassembly of intercellular junctions is a hallmark of epithelial-mesenchymal transition (EMT). However, how the junctions disassemble remains largely unknown. Here, we report that E3 ubiquitin ligase Smurf1 targets p120-catenin, a core component of adherens junction (AJ) complex, for monoubiquitin...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Wu, Qingang, Li, Gao, Wen, Chengwen, Zeng, Taoling, Fan, Yuxi, Liu, Chunyan, Fu, Guo-Feng, Xie, Changchuan, Lin, Qi, Xie, Liping, Huang, Lei, Pu, Pengpeng, Ouyang, Zhong, Chan, Hong-Lin, Zhao, Tong-Jin, Chen, Xiao Lei, Fu, Guo, Wang, Hong-Rui
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976293/
https://ncbi.nlm.nih.gov/pubmed/32010791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay9819
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