Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Transient plasma membrane disruptions (PMD) occur in osteocytes with in vitro and in vivo loading, initiating mechanotransduction. The goal here was to determine whether osteocyte PMD formation or repair is affected by aging. Osteocytes from old (24 months) mice developed fewer PMD (−76% females, −5...

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Bibliografiska uppgifter
I publikationen:Aging Cell
Huvudupphovsmän: Hagan, Mackenzie L., Yu, Kanglun, Zhu, Jiali, Vinson, Brooke N., Roberts, Rachel L., Montesinos Cartagena, Marlian, Johnson, Maribeth H., Wang, Liyun, Isales, Carlos M., Hamrick, Mark W., McNeil, Paul L., McGee‐Lawrence, Meghan E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974724/
https://ncbi.nlm.nih.gov/pubmed/31743583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13056
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