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Proteostasis failure and cellular senescence in long‐term cultured postmitotic rat neurons

Cellular senescence, a stress‐induced irreversible cell cycle arrest, has been defined for mitotic cells and is implicated in aging of replicative tissues. Age‐related functional decline in the brain is often attributed to a failure of protein homeostasis (proteostasis), largely in postmitotic neuro...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Ishikawa, Shoma, Ishikawa, Fuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974705/
https://ncbi.nlm.nih.gov/pubmed/31762159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13071
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