Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase

As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is a promising antibacterial drug target. Ebselen, an organo-selenium with well-characterized toxicology and pharmacology, was recently reported to have potent antibacterial activity against Staphylococcus aureus. In this paper, we demonstrat...

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Gepubliceerd in:Front Microbiol
Hoofdauteurs: Dong, Chuanjiang, Zhou, Jingxuan, Wang, Peng, Li, Tao, Zhao, Ying, Ren, Xiaoyuan, Lu, Jun, Wang, Jun, Holmgren, Arne, Zou, Lili
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Microbiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974526/
https://ncbi.nlm.nih.gov/pubmed/32010088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.03016
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