Endogenous T Cell Receptor Rearrangement Represses Aggressive Central Nervous System Autoimmunity in a TcR-Transgenic Model on the Non-Obese Diabetic Background

The T cell response to central nervous system (CNS) antigen in experimental autoimmune encephalomyelitis (EAE) permits one to model the immune aspects of multiple sclerosis. 1C6 transgenic mice on the non-obese diabetic (NOD) background possess a class II-restricted T cell receptor (TcR; Vα5-Vβ7) sp...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Yeola, Asmita Pradeep, Ignatius Arokia Doss, Prenitha Mercy, Baillargeon, Joanie, Akbar, Irshad, Mailhot, Benoit, Balood, Mohammad, Talbot, Sébastien, Anderson, Ana Carrizosa, Lacroix, Steve, Rangachari, Manu
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974510/
https://ncbi.nlm.nih.gov/pubmed/32010149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.03115
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