Challenges associated with homologous directed repair using CRISPR-Cas9 and TALEN to edit the DMD genetic mutation in canine Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene that abolish the expression of dystrophin protein. Dogs with the genetic homologue, golden retriever muscular dystrophy dog (GRMD), have a splice site mutation that leads to skipping of exon 7 and a stop codon in the DMD transc...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mata López, Sara, Balog-Alvarez, Cynthia, Vitha, Stanislav, Bettis, Amanda K., Canessa, Emily H., Kornegay, Joe N., Nghiem, Peter P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974172/
https://ncbi.nlm.nih.gov/pubmed/31961902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228072
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