SPLICELECT™: an adaptable cell surface display technology based on alternative splicing allowing the qualitative and quantitative prediction of secreted product at a single-cell level

We describe a mammalian expression construct (SPLICELECT™) that allows the redirection of a proportion of a secreted protein onto the cell surface using alternative splicing: whereas the majority of the RNA is spliced into a transcript encoding a secreted protein, a weak splice donor site yields a s...

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Pubblicato in:MAbs
Autori principali: Aebischer-Gumy, Christel, Moretti, Pierre, Ollier, Romain, Ries Fecourt, Christelle, Rousseau, François, Bertschinger, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2020
Soggetti:
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6973322/
https://ncbi.nlm.nih.gov/pubmed/31955651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1709333
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