CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

Cytomegalovirus (CMV) seropositivity in adults has been linked to increased cardiovascular disease burden. Phenotypically, CMV infection leads to an inflated CD8 T-lymphocyte compartment. We employed a 8-colour flow cytometric protocol to analyse circulating T cells in 597 octogenarians from the sam...

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Veröffentlicht in:NPJ Aging Mech Dis
Hauptverfasser: Martin-Ruiz, Carmen, Hoffmann, Jedrzej, Shmeleva, Evgeniya, Zglinicki, Thomas von, Richardson, Gavin, Draganova, Lilia, Redgrave, Rachael, Collerton, Joanna, Arthur, Helen, Keavney, Bernard, Spyridopoulos, Ioakim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Brief Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972903/
https://ncbi.nlm.nih.gov/pubmed/31993214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41514-019-0041-y
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