Intramuscular Botulinum toxin A injections induce central changes to axon initial segments and cholinergic boutons on spinal motoneurones in rats

Intramuscular injections of botulinum toxin block pre-synaptic cholinergic release at neuromuscular junctions producing a temporary paralysis of affected motor units. There is increasing evidence, however, that the effects are not restricted to the periphery and can alter the central excitability of...

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Published in:Sci Rep
Main Authors: Jensen, D. B., Klingenberg, S., Dimintiyanova, K. P., Wienecke, J., Meehan, C. F.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972769/
https://ncbi.nlm.nih.gov/pubmed/31964988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57699-z
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