Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals

BACKGROUND: Individuals genetically susceptible to malignant hyperthermia (MH) exhibit hypermetabolic reactions when exposed to volatile anaesthetics. Mitochondrial dysfunction has previously been associated with the MH-susceptible (MHS) phenotype in animal models, but evidence of this in human MH i...

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Udgivet i:Br J Anaesth
Main Authors: Chang, Leon, Daly, Catherine, Miller, Dorota M., Allen, Paul D., Boyle, John P., Hopkins, Philip M., Shaw, Marie-Anne
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Clinical Practice
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972232/
https://ncbi.nlm.nih.gov/pubmed/30916033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2019.02.010
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